A comprehensive analysis of metabolomics and transcriptomics reveals new biomarkers and mechanistic insights on DEHP exposures in MCF-7 cells

作者: Yu-Shun Lu , Gui-Xiao Yao , Xin-Lu Wang , Jia-Xi Liu , Jiang Yu

DOI: 10.1016/J.CHEMOSPHERE.2020.126865

关键词:

摘要: … Transcriptomic profiling was used to … metabolites and genes associated with DEHP exposure. Our data revealed for the first time that metabolites and genes related to purine metabolism …

参考文章(41)
Philip W. Ingham, Yoshiro Nakano, Claudia Seger, Mechanisms and functions of Hedgehog signalling across the metazoa Nature Reviews Genetics. ,vol. 12, pp. 393- 406 ,(2011) , 10.1038/NRG2984
Narender Kumar, Shruti Sharan, Swati Srivastava, Partha Roy, None, Assessment of estrogenic potential of diethyl phthalate in female reproductive system involving both genomic and non-genomic actions. Reproductive Toxicology. ,vol. 49, pp. 12- 26 ,(2014) , 10.1016/J.REPROTOX.2014.06.008
Li Chen, Yan Zhao, Luxi Li, Bingheng Chen, Yunhui Zhang, Exposure assessment of phthalates in non-occupational populations in China Science of The Total Environment. ,vol. 427-428, pp. 60- 69 ,(2012) , 10.1016/J.SCITOTENV.2012.03.090
Alexandre Eveillard, Frédéric Lasserre, Marie de Tayrac, Arnaud Polizzi, Sandrine Claus, Cécile Canlet, Laïla Mselli-Lakhal, Gaëlle Gotardi, Alain Paris, Hervé Guillou, Pascal GP Martin, Thierry Pineau, Identification of potential mechanisms of toxicity after di-(2-ethylhexyl)-phthalate (DEHP) adult exposure in the liver using a systems biology approach. Toxicology and Applied Pharmacology. ,vol. 236, pp. 282- 292 ,(2009) , 10.1016/J.TAAP.2009.02.008
Youn-Jung Kim, Eun-young Kim, Jae-Chun Ryu, Identification of estrogenic genes responding to phthalate esters treatment in human MCF-7 cells Molecular & Cellular Toxicology. ,vol. 7, pp. 163- 170 ,(2011) , 10.1007/S13273-011-0022-0
Patrick S. Ward, Craig B. Thompson, Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate Cancer Cell. ,vol. 21, pp. 297- 308 ,(2012) , 10.1016/J.CCR.2012.02.014
Ronald Biemann, Anne Navarrete Santos, Alexander Navarrete Santos, Dagmar Riemann, Julia Knelangen, Matthias Blüher, Holger Koch, Bernd Fischer, Endocrine disrupting chemicals affect the adipogenic differentiation of mesenchymal stem cells in distinct ontogenetic windows. Biochemical and Biophysical Research Communications. ,vol. 417, pp. 747- 752 ,(2012) , 10.1016/J.BBRC.2011.12.028
Fong-Sen Wu, Terrell T. Gibbs, David H. Farb, Dual activation of GABAA and glycine receptors by β-alanine : inverse modulation by progesterone and 5α-pregnan-3α-ol-20-one European Journal of Pharmacology. ,vol. 246, pp. 239- 246 ,(1993) , 10.1016/0922-4106(93)90037-A