Neuronal Release of Vasoactive Intestinal Peptide Is Important to Astrocytic Protection of Neurons from Glutamate Toxicity
作者： David R. Brown
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摘要: Astrocytes regulate clearance of glutamate from the vicinity neurons. This helps to protect neurons directly toxicity. Recent findings have indicated that a complex molecular interaction between and astrocytes is necessary for this protection occurs. In present investigation role vasoactive intestinal peptide (VIP) in signaling was investigated. VIP found be protective effects coculture system. combination with neuronal-conditioned medium enhanced uptake by astrocytes. Also, expression high-affinity receptor, increased astrocytic release interleukin-6, indirectly reduced toxicity astrocyte medium. These results indicate essential involved regulation
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