Vitamin D insufficiency in a population of healthy western Canadians

摘要: Background: People with low levels of vitamin D and its metabolites are at increased risk for osteoporotic fractures. We wished to ascertain in a representative sample adult western Canadians, help assess the level risk. evaluated prevalence insufficiency, defined as 25-hydroxyvitamin [25(OH)D] less than 40 nmol/L, seasonal variations 25(OH)D, parathyroid hormone related biochemical indices community-dwelling population healthy Canadians living Calgary (lati- tude 51°079N). Methods: During calendar year 1999, we collected fasting overnight blood samples every 3 months from 60 men 128 women (age range 27 89 years) who had volunteered participate another study. used commercial radioimmunoassay kits measure calciotrophic hormones other indices. Regression models longitudinal data were effect season potential predictors on individual parameters. Results: For total 64 participants (34%), 25(OH)D was recorded least once out 4 sampling times. After adjustment age, body mass index holiday travel, observed anticipated rise serum mean 57.3 (standard deviation [SD] 21.3) nmol/L winter 62.9 (SD 28.8) spring ( p = 0.001) 71.6 23.6) summer 0.008). The inverse relation between not consistently observed: after sex, calcium, did decrease significantly, 39.5 18.8) ng/L 36.3 17.8) 0.001), but they continued decline 34.5 17.3) fall 0.21). Interpretation: documented high which warrants consideration dietary supplementation.