Molecular and Genomic Alterations in Glioblastoma Multiforme.
作者： Ines Crespo , Ana Louisa Vital , María Gonzalez-Tablas , María del Carmen Patino , Alvaro Otero
DOI: 10.1016/J.AJPATH.2015.02.023
关键词:
摘要: In recent years, important advances have been achieved in the understanding of molecular biology glioblastoma multiforme (GBM); thus, complex genetic alterations and genomic profiles, which recurrently involve multiple signaling pathways, defined, leading to first molecular/genetic classification disease. this regard, different pathways appear distinguish primary (eg, EGFR amplification) versus secondary IDH1/2 or TP53 mutation) GBM. Such target distinct combinations growth factor receptor–ras as well phosphatidylinositol 3-kinase/phosphatase tensin homolog/AKT, retinoblastoma/cyclin-dependent kinase (CDK) N2A-p16 INK4A , TP53/mouse double minute (MDM) 2/MDM4/CDKN2A-p14 ARF cells that present features associated with key stages normal neurogenesis (normal) central nervous system cell types. This translates into well-defined profiles recently classified by The Cancer Genome Atlas Consortium four subtypes: classic, mesenchymal, proneural, neural Herein, we review most relevant GBM, specific involved, overall profile genetically heterogeneous group malignant tumors.
sci-hub.se 参考文章(100)
Nanne K. Kloosterhof, Johan J. de Rooi, Max Kros, Paul H. C. Eilers, Peter A. E. Sillevis Smitt, Martin J. van den Bent, Pim J. French, Molecular subtypes of glioma identified by genome-wide methylation profiling. Genes, Chromosomes and Cancer. ,vol. 52, pp. 665- 674 ,(2013) , 10.1002/GCC.22062
Rebecca A. Betensky, Andreas Von Deimling, J. Gregory Cairncross, Catherine L. Nutt, Todd R. Golub, Todd R. Golub, Ute Pohl, Peter M. Black, David N. Louis, Scott L. Pomeroy, Tracy T. Batchelor, Christine Ladd, Margaret E. McLaughlin, Pablo Tamayo, D. R. Mani, Christian Hartmann, Gene expression-based classification of malignant gliomas correlates better with survival than histological classification. Cancer Research. ,vol. 63, pp. 1602- 1607 ,(2003)
Rafael Benito, Rosario Gil-Benso, Vicente Quilis, Miguel Perez, Mariela Gregori-Romero, Pedro Roldan, Jose Gonzalez-Darder, Miguel Cerdá-Nicolas, Concha Lopez-Gines, Primary glioblastomas with and without EGFR amplification: Relationship to genetic alterations and clinicopathological features Neuropathology. ,vol. 30, pp. 392- 400 ,(2009) , 10.1111/J.1440-1789.2009.01081.X
Nicola Montano, Tonia Cenci, Maurizio Martini, Quintino Giorgio D’Alessandris, Federica Pelacchi, Lucia Ricci-Vitiani, Giulio Maira, Ruggero De Maria, Luigi Maria Larocca, Roberto Pallini, Expression of EGFRvIII in glioblastoma: prognostic significance revisited. Neoplasia. ,vol. 13, pp. 1113- 1121 ,(2011) , 10.1593/NEO.111338
Yuchen Jiao, Patrick J. Killela, Zachary J. Reitman, B. Ahmed Rasheed, Christopher M. Heaphy, Roeland F. de Wilde, Fausto J. Rodriguez, Sergio Rosemberg, Sueli Mieko Oba-Shinjo, Suely Kazue Nagahashi Marie, Chetan Bettegowda, Nishant Agrawal, Eric Lipp, Christopher J. Pirozzi, Giselle Y. Lopez, Yiping He, Henry S. Friedman, Allan H. Friedman, Gregory J. Riggins, Matthias Holdhoff, Peter Burger, Roger E. McLendon, Darell D. Bigner, Bert Vogelstein, Alan K. Meeker, Kenneth W. Kinzler, Nickolas Papadopoulos, Luis A. Diaz, Hai Yan, Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. Oncotarget. ,vol. 3, pp. 709- 722 ,(2012) , 10.18632/ONCOTARGET.588
S. Zhao, Y. Lin, W. Xu, W. Jiang, Z. Zha, P. Wang, W. Yu, Z. Li, L. Gong, Y. Peng, J. Ding, Q. Lei, K.-L. Guan, Y. Xiong, Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α Science. ,vol. 324, pp. 261- 265 ,(2009) , 10.1126/SCIENCE.1170944
Mitsutoshi Nakamura, Yasuhiro Yonekawa, Paul Kleihues, Hiroko Ohgaki, Promoter hypermethylation of the RB1 gene in glioblastomas. Laboratory Investigation. ,vol. 81, pp. 77- 82 ,(2001) , 10.1038/LABINVEST.3780213
Mitsutoshi Nakamura, Eiwa Ishida, Keiji Shimada, Munehiro Kishi, Hiroyuki Nakase, Toshisuke Sakaki, Noboru Konishi, Frequent LOH on 22q12.3 and TIMP-3 inactivation occur in the progression to secondary glioblastomas. Laboratory Investigation. ,vol. 85, pp. 165- 175 ,(2005) , 10.1038/LABINVEST.3700223
Hironori Fujisawa, Rui M Reis, Mitsutoshi Nakamura, Stefano Colella, Yasuhiro Yonekawa, Paul Kleihues, Hiroko Ohgaki, None, Loss of heterozygosity on chromosome 10 is more extensive in primary (de novo) than in secondary glioblastomas. Laboratory Investigation. ,vol. 80, pp. 65- 72 ,(2000) , 10.1038/LABINVEST.3780009
Hideyuki Arita, Yoshitaka Narita, Shintaro Fukushima, Kensuke Tateishi, Yuko Matsushita, Akihiko Yoshida, Yasuji Miyakita, Makoto Ohno, V. Peter Collins, Nobutaka Kawahara, Soichiro Shibui, Koichi Ichimura, Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss Acta Neuropathologica. ,vol. 126, pp. 267- 276 ,(2013) , 10.1007/S00401-013-1141-6