Monomeric calcitonin secretion in infants with congenital hypothyroidism.

摘要: We have determined CT levels in whole serum (iCT) and by an extraction method (exCT) 25 infants affected congenital hypothyroidism (CH)--11 athyreotic 14 dysgenetic--at age days, before the institution of therapy, at 2 years. In hypothyroid patients days iCT exCT were similar to those found controls same age. At years decreased both groups patients. However, whereas hypothyroids age, significantly lower than controls; moreover they dysgenetic this after calcium infusion, increased but not hypothesize that deficiency CH is due degradation human substitutive which, stimulating proteolytic enzymes, destroys biologic activity CT. An procedure improves sensitivity specificity assay it must be used when suspected. addition we suggest measurement Ca infusion might useful distinguish from