Monomeric serum calcitonin and bone turnover during anticonvulsant treatment and in congenital hypothyroidism.

摘要: Decreased basal and calcium-stimulated calcitonin serum levels have been found in children with congenital hypothyroidism those receiving anticonvulsant drugs. The purpose of our investigation was to confirm these results using a new technique for measurement study the effect on bone turnover. Calcitonin were measured two different antibodies before after low-dose Ca infusion patients phenytoin, primidone, carbamazepine, or valproate recelving l -thyroxine. In comparison control values, Ca-stimulated extractable calcitonin, representing monomeric biologically active form hormone, moderately decreased epilepsy phenytoin severely hypothyroidism. metabolism normal, except an elevated renal threshold phosphate (indicating conservation) increased fasting urinary excretion hydroxyproline resorption) secretory capacity C cells is treatment some, but not all, drugs, lacking Patients deficiency may be prone osteopenia if tendency osteoclastic activity aggravated by secondary hyperparathyroidism primidone inappropriate thyroid replacement therapy