Nature of the Stimulus Leading to Lymphocyte-Induced Angiogenesis

摘要: Experiments are described that characterize the nature of stimulus leading to lymphocyte-induced angiogenesis (LIA), a reaction previously shown reflect local in vivo graft- vs -host reaction. The studies demonstrate circulating cells host animals provide stimulation essential for activation donor lymphocytes and major allogeneic congenic lines mice is correlated with I-region disparity, primarily associated I A -controlled determinants. results readily compartible hypothesis proposed LIA large part consequence release soluble mediators or lymphokines may act either directly on endothelial indirectly by activating macrophages, which turn generate vascular