A randomized controlled trial to evaluate the slow-acting symptom-modifying effects of colchicine in osteoarthritis of the knee: a preliminary report.

摘要: Objective To determine if colchicine added to nimesulide may have a beneficial effect on osteoarthritis (OA) of the knee. Methods Colchicine 0.5 mg twice daily or placebo was (a nonsteroidal antiinflammatory drug) in 36 patients with OA knee randomized, double-blind, placebo-controlled trial over 5-month period. Results The 30% improvement rate at 20 weeks higher group than control receiving placebo, as measured by total Western Ontario and McMaster University Osteoarthritis scores (57.9% versus 23.5%) visual analog scale for index pain (52.6% 17.6%) (primary measures response). The significance persisted combined analysis Mantel-Haenszel test (P = 0.062). Comparison means also showed significant multivariate performed using T2 0.0115). Conclusion Among knee, plus exhibited significantly greater symptomatic benefit did placebo.