Using the Collaborative Cross to Study the Role of Genetic Diversity in Cancer-Related Phenotypes.

摘要: Human populations are genetically diverse and often a single mouse model can only represent small subset of the human population. Studying genetic diversity directly improve predictive value models cancer biology research on effects carcinogens therapeutics in humans. The collaborative cross is panel inbred lines that captures 90% Mus musculus strain help identify regions genome responsible for variation phenotypes across appropriate procedure will depend used; here, three designs described as examples.