Fibrin-stabilizing factor (factor XIII).
作者： C.G. Curtis , L. Lorand
DOI: 10.1016/S0076-6879(76)45018-8
关键词:
摘要: Publisher Summary Fibrin-stabilizing factor (FSF, XIII) is the inactive precursor in blood plasma for enzyme fibrinoligase (activated FSF, FXIIIa). This transamidase performs essential hemostatic function of catalyzing formation intermolecular 7-glutamyl-c-lysine bridges between fibrin molecules, which greatly augments physical stiffness clot structure and its resistance to lysis. The may also be involved strengthening attachment network disrupted platelet membranes surface fibroblasts, latter being conceivably important wound healing. During coagulation, fibrin-stabilizing zymogen converted active two distinct consecutive steps. first requires only thrombin, second involves a specific interaction thrombin-modified with calcium ions only. chapter discusses slightly modified method original obtaining XIII from citrated outdated bank human (or oxalated bovine plasma) by salt-gradient DEAE-Cellulose chromatographic procedure, as described Lorand Gotoh. procedure has been widely used clinical research, genetic appraisal hereditary deficieney; evaluating transfusions administered deficient individual identifying circulating acquired inhibitors hemorrhagic disorders stabilization.
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