Overview of the Knottin scorpion toxin-like peptides in scorpion venoms: Insights on their classification and evolution.

摘要: Scorpion venoms include several compounds with different pharmacological activities. Within these compounds, toxins affecting ion channels are among the most studied. They all peptides that have been classified based on their 3D structure, chain size and function. Usually, they show a spatial arrangement characterized by presence of cysteine-stabilized alpha beta motif; them affect Na(+) K(+) ion-channels. These features revised in occasions before, but complete phylogenetic analysis disulfide containing is not done. In present contribution, two databases (Pfam InterPro) including more than 800 from scorpions were analyzed. Pfam database included organisms other such as insects plants, while InterPro only scorpion toxins. Our results suggest evolved independently those no matter length peptidic chains. preliminary current classification needs detailed revision, order to better toxin families, so new obtained transcriptomic analyses would be properly classified.