Meta-analysis confirms a role for deletion in FCGR3B in autoimmune phenotypes
作者： Cushla McKinney , Tony R. Merriman
DOI: 10.1093/HMG/DDS039
关键词:
摘要: Although deletion in the low-affinity IgG receptor gene FCGR3B has repeatedly been implicated systemic autoimmune disease, role of copy number variation (CNV) autoimmunity still remains unclear. Factors such as study size, ethnicity, specific disease phenotype and experimental methodology may explain these conflicting results. Here we aimed at using meta-analysis to assess for CNV autoimmunity. We excluded studies SybrGreen-based genotyping found strong evidence association between low (<2) CN lupus erythematosus [OR = 1.59 (1.32-1.92), P(meta)=9.1 × 10(-7)], but not rheumatoid arthritis 1.36 (0.89-2.06), P= 0.15]. However, a combined analysis supports risk factor non-organ-specific 1.44 (1.28-1.62), P(meta)= 2.9 10(-9)]. This implicates clearance immune complex etiology disease.
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Willemijn B. Breunis, Edwin van Mirre, Marrie Bruin, Judy Geissler, Martin de Boer, Marjolein Peters, Dirk Roos, Masja de Haas, Harry R. Koene, Taco W. Kuijpers, Copy number variation of the activating FCGR2C gene predisposes to idiopathic thrombocytopenic purpura. Blood. ,vol. 111, pp. 1029- 1038 ,(2008) , 10.1182/BLOOD-2007-03-079913
Edward J. Hollox, Jan-Christoph Detering, Tushna Dehnugara, An integrated approach for measuring copy number variation at the FCGR3 (CD16) locus. Human Mutation. ,vol. 30, pp. 477- 484 ,(2009) , 10.1002/HUMU.20911
W. Qiu, D de Bruin, B. Brownstein, R Pearse, J. Ravetch, Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination. Science. ,vol. 248, pp. 732- 735 ,(1990) , 10.1126/SCIENCE.2139735
James I Robinson, Ian M Carr, Dawn L Cooper, Lubna H Rashid, Stephen G Martin, Paul Emery, John D Isaacs, Anne Barton, BRAGGSS, Anthony G Wilson, Jennifer H Barrett, Ann W Morgan, None, Confirmation of association of FCGR3B but not FCGR3A copy number with susceptibility to autoantibody positive rheumatoid arthritis. Human Mutation. ,vol. 33, pp. 741- 749 ,(2012) , 10.1002/HUMU.22031
Stylianos Bournazos, Irini Bournazou, John T. Murchison, William A. Wallace, Pauline McFarlane, Nikhil Hirani, A. John Simpson, Ian Dransfield, Simon P. Hart, Copy number variation of FCGR3B is associated with susceptibility to idiopathic pulmonary fibrosis. Respiration. ,vol. 81, pp. 142- 149 ,(2011) , 10.1159/000321997
Chris Barnes, Vincent Plagnol, Tomas Fitzgerald, Richard Redon, Jonathan Marchini, David Clayton, Matthew E Hurles, A robust statistical method for case-control association testing with copy number variation Nature Genetics. ,vol. 40, pp. 1245- 1252 ,(2008) , 10.1038/NG.206
K A Davies, A M Peters, H L Beynon, M J Walport, Immune complex processing in patients with systemic lupus erythematosus. In vivo imaging and clearance studies. Journal of Clinical Investigation. ,vol. 90, pp. 2075- 2083 ,(1992) , 10.1172/JCI116090
Michael W. Fanger, Li Shen, Robert F. Graziano, Paul M. Guyre, Cytotoxicity mediated by human Fc receptors for IgG Immunology Today. ,vol. 10, pp. 92- 99 ,(1989) , 10.1016/0167-5699(89)90234-X
H. Yang, Q. Zhou, DJ Chen, H. Jiang, YY Mao, JH Chen, The single nucleotide polymorphisms gene but not the copy number variation of Fcgr3B is associated with lupus nephritis in Chinese people Lupus. ,vol. 19, pp. 662- 664 ,(2010) , 10.1177/0961203309350754
Kouichi Asano, Tomonaga Matsushita, Junji Umeno, Naoya Hosono, Atsushi Takahashi, Takahisa Kawaguchi, Takayuki Matsumoto, Toshiyuki Matsui, Yoichi Kakuta, Yoshitaka Kinouchi, Tooru Shimosegawa, Masayo Hosokawa, Yoshiaki Arimura, Yasuhisa Shinomura, Yutaka Kiyohara, Tatsuhiko Tsunoda, Naoyuki Kamatani, Mitsuo Iida, Yusuke Nakamura, Michiaki Kubo, A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population. Nature Genetics. ,vol. 41, pp. 1325- 1329 ,(2009) , 10.1038/NG.482