Copy number variation of FCGR3B is associated with susceptibility to idiopathic pulmonary fibrosis.

摘要: Background: Several genes exhibit copy number variation (CNV), including FCGR3B which encodes the IgG receptor FcγRIIIb. Engagement of Fcγ receptors by complexes may contribute to pathogenesis idiopathic pulmonary fibrosis (IPF). Objectives: To investigate whether CNV is associated with susceptibility IPF. Methods: In a case-control study we compared in 142 patients IPF and 221 controls real-time quantitative PCR using CD36 as gene control. Results: Significantly increased FCGR3B:CD36 ratio was evident cohort (p = 0.009). Association further confirmed likelihood statistical approach 0.003). assignment based on ratios revealed significant skewing distribution between controls. cohort, there frequency >2 copies (0.30 vs. 0.19; χ2 9.27; d.f. 2; p 0.0097). The presence higher risk 0.01, OR: 1.914, 95% CI: 1.17–3.12). Conclusions: These findings support an association propose novel role for disease pathogenesis.