Endothelial adhesion molecules in glomerular lesions: Association with their severity and diversity in lupus models

摘要: Endothelial adhesion molecules in glomerular lesions: Association with their severity and diversity lupus models. Background To clarify whether vascular endothelial glomeruli might contribute to the of lesions nephritis, expression models was analyzed. Methods The levels E- P-selectin cell molecule-1 (VCAM-1) different histopathologic grades MRL/MpJ- lpr/lpr (MRL/lpr) mice studied using laser-capture microdissection glomeruli, followed by reverse transcription-polymerase chain reaction (RT-PCR) analysis. SCID injected 2B11.3 7B6.8 clones, which are derived from an MRL/lpr mouse induce endocapillary proliferative wire loop type lesions, respectively, were investigate effect a soluble form E-selectin (sE-selectin) on development sE-selectin–producing L cells prepared transfection cDNA encoding sE-selectin into mice. Results showed increased these molecules, corresponding lesions. induced clone significantly especially P-selectin, but lesion expressed only VCAM-1. Formation markedly prevented association elevation serum level produced tansfected cells. Conclusion histopathology nephritis partially associated glomeruli.