Elevated Urinary VCAM-1, P-Selectin, Soluble TNF Receptor-1, and CXC Chemokine Ligand 16 in Multiple Murine Lupus Strains and Human Lupus Nephritis

摘要: In an effort to identify potential biomarkers in lupus nephritis, urine from mice with spontaneous nephritis was screened for the presence of VCAM-1, P-selectin, TNFR-1, and CXCL16, four molecules that had previously been shown be elevated experimental immune particularly at peak disease. Interestingly, all were approximately 2- 4-fold several strains including MRL/lpr, NZM2410, B6.Sle1.lpr strains, correlating well proteinuria. CXCL16 enriched compared serum active disease, expressed within diseased kidneys. Finally, also patients protein levels systemic erythematosus disease activity index scores. particular, urinary VCAM-1 showed superior specificity sensitivity distinguishing subjects renal other patients. These studies uncover as a quartet may have diagnostic significance nephritis. Longitudinal are warranted establish clinical use these biomarkers.