Autologous Bone-Marrow Mononuclear Cell Implantation Improves Endothelium-Dependent Vasodilation in Patients With Limb Ischemia
作者： Yukihito Higashi , Masashi Kimura , Keiko Hara , Kensuke Noma , Daisuke Jitsuiki
DOI: 10.1161/01.CIR.0000121427.53291.78
关键词:
摘要: Background— Patients with limb ischemia were associated endothelial dysfunction. The purpose of this study was to determine whether autologous bone-marrow mononuclear cell (BM-MNC) implantation improves dysfunction in patients ischemia. Methods and Results— We evaluated the leg blood flow (LBF) response acetylcholine (ACh), an endothelium-dependent vasodilator, sodium nitroprusside (SNP), endothelium-independent before after BM-MNC 7 LBF measured a mercury-filled Silastic strain-gauge plethysmograph. number BM-MNCs implanted into ischemic limbs 1.6×109±0.3×109. CD34+ cells included 3.8×107±1.6×107. improved ankle-brachial pressure index (0.33±0.21 0.39±0.17, P=0.06), transcutaneous oxygen (28.4±11.5 36.6±5.2 mm Hg, P=0.03), pain-free walking time (0.8±0.6 2.9±2.2 minutes, P=0.02). After implant...
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