Endogenous opioids and feeding behavior: a 30-year historical perspective.

摘要: This invited review, based on the receipt of Third Gayle A. Olson and Richard D. Prize for publication outstanding behavioral article published in journal Peptides 2002, examines 30-year historical perspective role endogenous opioid system feeding behavior. The review focuses advances that this field has made over past 30 years as a result timely discoveries were concerning important neuropeptide system, how these quickly applied to analysis behavior attendant homeostatic processes. receptors peptides, establishment their relevance pivotal studies performed 1970s. 1980s characterized by receptor subtype agonists antagonists modulation well use general demonstrating wide array ingestive situations paradigms involving system. more recent work from 1990s present, utilizes advantages created cloning genes, development knockout knockdown techniques, systematic utilization systems neuroscience approach, reciprocity manipulations peptides affect with states levels receptors. G-protein effector opioid-mediated responses, which was subject prize-winning article, is then reviewed.