Homeo box genes in murine development.

摘要: Considerable information has accumulated on mouse homeo box gene organization and expression. Homeo genes are expressed in a wide variety of tissues, developmental stages, cell lines. How can this be interpreted view the relationship these to Drosophila morphogenetic loci? One is that control determinative decisions by modulating transcription as yet unidentified target genes. Proponents faced with two tasks: identify processes controlled genes, mediate control. Such might identified basis vitro domain-DNA interactions. Candidate observed patterns It must stressed finding expression given tissue no way demonstrates necessary for determination tissue. The role based upon analysis mutants demonstrate pattern determines outcome. To test whether involved decision, one disrupt normal observe resulting effect. In approached looking allelism known loci, isolating through large-scale mutagenesis screens, or introducing altered into transgenic mice. most intriguing possibilities regional specification along anteroposterior axis. situ hybridization Northern blot have demonstrated at least four different display distinct axis developing CNS. each unique anterior boundary from which extends posteriorly within Hox 1.5 an hindbrain just posterior pontine flexure. 2.1 lies more medulla hindbrain. Weak 2.5 detected spinal cord first cervical vertebra, maximal found second vertebra.(ABSTRACT TRUNCATED AT 400 WORDS)