L-2-Oxothiazolidine-4-Carboxylate as a Cysteine Precursor: Efficacy for Growth and Hepatic Glutathione Synthesis in Chicks and Rats

摘要: Chick and rat experiments were conducted to determine the efficacy of L-2-oxothiazolidine-4-carboxylate (OTC) as a cysteine (Cys) precursor for growth hepatic glutathione (GSH) biosynthesis. Isosulfurous graded increments OTC Cys added Cys-free purified amino acid diets that adequate in methionine. Curvilinear responses both chicks rats obtained. Hepatic GSH accumulated only at dietary levels above 0.10%. In rats, increased linearly content from deficient excessive. Utilization by was efficacious isosulfurous slightly inferior Exponential regression slope-ratio values 78.5% 70.2% rats; multiple linear biosynthesis 80.3% 83.7% rats. It is concluded orally administered active precursor.