Comparison of tissue distribution of two novel serine/threonine kinase genes containing the LIM motif (LIMK-1 and LIMK-2) in the developing rat.
作者： Tetsuji Mori , Ichiro Okano , Kensaku Mizuno , Masaya Tohyama , Akio Wanaka
DOI: 10.1016/S0169-328X(96)00257-4
关键词:
摘要: We previously isolated two novel serine/threonine kinase genes containing the LIM motif (LIMK-1 and LIMK-2) from a rat cDNA library. To examine functions of these genes, we performed in situ hybridization developing nervous system. LIMK-1 LIMK-2 mRNAs mostly co-localized during development are expressed preferentially central system mid-to-late gestation but signals decreased post-natal period. However, differential gene expression was observed some nuclei CNS; mRNA intensely facial motor nucleus, hypoglossal deep cerebellum layers 3, 5 6 adult cerebral cortex while only parts epithelium. In nasal cavity, were complementarily. Our results suggest that may have different regions development.
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