摘要: Neurofilament proteins and the neuron-specific microtubule-associated protein tau are phosphorylated in vivo at sites conforming to phosphorylation consensus motif of cell-cycle-control kinase, p34cdc2-cyclin. Abnormalities these associated with neurodegenerative disorders, such as amylotrophic lateral sclerosis Alzheimer's disease. A cdc2-like kinase composed cyclin-dependent 5 (cdk5) a brain-specific regulatory subunit is proposed be responsible for neuronal proteins.
elsevier.com
sci-hub.se 参考文章(39)
K.L. Gould, S. Moreno, D.J. Owen, S. Sazer, P. Nurse, Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function. The EMBO Journal. ,vol. 10, pp. 3297- 3309 ,(1991) , 10.1002/J.1460-2075.1991.TB04894.X
Matthew Meyerson, Greg H Enders, Chin-Lee Wu, LK Su, C Gorka, C Nelson, Ed Harlow, LH Tsai, A family of human cdc2-related protein kinases. The EMBO Journal. ,vol. 11, pp. 2909- 2917 ,(1992) , 10.1002/J.1460-2075.1992.TB05360.X
J Lew, R.J. Winkfein, H.K. Paudel, J.H. Wang, Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2. Journal of Biological Chemistry. ,vol. 267, pp. 25922- 25926 ,(1992) , 10.1016/S0021-9258(18)35696-5
H. Ishiguro, K.T. Kim, T.H. Joh, K.S. Kim, Neuron-specific expression of the human dopamine beta-hydroxylase gene requires both the cAMP-response element and a silencer region. Journal of Biological Chemistry. ,vol. 268, pp. 17987- 17994 ,(1993) , 10.1016/S0021-9258(17)46802-5
R Vulliet, S.M. Halloran, R.K. Braun, A.J. Smith, G Lee, Proline-directed phosphorylation of human Tau protein. Journal of Biological Chemistry. ,vol. 267, pp. 22570- 22574 ,(1992) , 10.1016/S0021-9258(18)41710-3
Z.S. Xu, W.S. Liu, M.B. Willard, Identification of six phosphorylation sites in the COOH-terminal tail region of the rat neurofilament protein M. Journal of Biological Chemistry. ,vol. 267, pp. 4467- 4471 ,(1992) , 10.1016/S0021-9258(18)42856-6
M Mawal-Dewan, P.C. Sen, M Abdel-Ghany, D Shalloway, E Racker, Phosphorylation of tau protein by purified p34cdc28 and a related protein kinase from neurofilaments. Journal of Biological Chemistry. ,vol. 267, pp. 19705- 19709 ,(1992) , 10.1016/S0021-9258(18)41832-7
Y. Gu, J. Rosenblatt, D.O. Morgan, Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. The EMBO Journal. ,vol. 11, pp. 3995- 4005 ,(1992) , 10.1002/J.1460-2075.1992.TB05493.X
F L Hall, J P Mitchell, P R Vulliet, Phosphorylation of synapsin I at a novel site by proline-directed protein kinase. Journal of Biological Chemistry. ,vol. 265, pp. 6944- 6948 ,(1990) , 10.1016/S0021-9258(19)39241-5
J Lew, K Beaudette, C.M. Litwin, J.H. Wang, Purification and characterization of a novel proline-directed protein kinase from bovine brain. Journal of Biological Chemistry. ,vol. 267, pp. 13383- 13390 ,(1992) , 10.1016/S0021-9258(18)42222-3