Decreased Expression of Murine PPARγ in Adipose Tissue during Endotoxemia

摘要: Infection-induced hyperlipidemia develops due to a combination of factors, one which is decreased clearance lipids from the bloodstream depressed synthesis lipoprotein lipase (LPL). Recently, peroxisome proliferator activated receptors (PPARs) have been shown be important in regulation LPL, particularly PPARγ. PPARγ and its heterodimerization partner, RXRα transcriptional activators LPL co-transfection analysis. Therefore, we hypothesized that decrease expression during endotoxemia may result expression. In these studies, examined effect endotoxin or proximal mediator, tumor necrosis factor (TNF), on white (WAT) brown adipose tissue (BAT) CD-1 mice. We report treatment with endotoxin, but not TNF, transiently mRNA levels 4 hr after treatment. However, TNF protein 18 hr, was at time when ...