Antibody levels to Malassezia pachydermatis and Staphylococcus pseudintermedius in atopic dogs and their relationship with lesion scores.

摘要: BACKGROUND: Elevated immunoglobulin E (IgE) levels to Malassezia or Staphylococcus species in human atopic dermatitis are related the skin severity index; a similar association has not been reported dogs. OBJECTIVES: To investigate serum of allergen‐specific IgE, total specific IgG and subclasses (IgG1 IgG2) for M. pachydermatis S. pseudintermedius, correlate them with ANIMALS: Serum samples were collected from dogs categorized by age disease status. Groups 1 2: <3‐year‐old healthy (n = 9) (n = 9), respectively; groups 3 4: ≥3‐year‐old (n = 11) (n = 14), respectively. METHODS AND MATERIALS: Antibody measured ELISA. The Canine Atopic Dermatitis Lesion Index (CADLI) was analyzed relation antibody levels. RESULTS: Specific IgE against S. pseudintermedius significantly increased all ages. Although differences between dogs, regard IgG1 IgG2 each microbe, varied significance within groups. No significant relationships found CADLI any both microbe types. CONCLUSIONS CLINICAL IMPORTANCE: In dog skin, microbes may act as allergens triggering inflammatory responses via IgE‐ IgG‐dependent pathway(s). affinity subclass produced vary according antigen type. be clinical lesion severity.