Superior Frontal Sulcus Focal Cortical Dysplasia Type II: An MRI, PET, and Quantified SEEG Study.

摘要: Purpose: The superior frontal sulcus (SFS), located in the prefrontal and premotor cortex, is considered as one of common locations focal cortical dysplasia (FCD). However, characteristics seizures arising from this area are incompletely known. primary purpose study was to investigate clinical features epileptic networks originating SFS. Methods: We included seventeen patients with type II FCD within SFS identified both visually automatically. Semiological were evaluated grouped. Interictal 18FDG-PET imaging all compared controls using statistical parametric mapping (SPM-PET). In those subjects stereoelectroencephalography (SEEG), two different quantitative intracranial electroencephalography analyses applied. Finally, SFS-related hypometabolic regions epileptogenic zones (EZs) transformed into standard space for group analysis. Results: semiological groups. Group 1 (9/17) showed elementary motor signs (head version tonic posturing), while 2 (8/17) exhibited complex behavior (fear, hypermotor, ictal pouting). Based on SPM-PET, an SFS-supplementary (SMA) propagation network found 1, SFS-middle cingulate cortex (MCC)-pregenual anterior (pACC) discovered 2. Intracranial EEG analysis suggested similar affected structures high epileptogenicity. EZs these groups a posterior-anterior spatial relationship. Conclusions: Even though spatially restricted can be divided based features. SFS-SMA SFS-MCC-pACC may play pivotal roles generation semiologies. relationship provides potentially useful information distinguishing types surgical evaluation.