In vitroantifungal activity of antipsychotic drugs and their combinations with conventional antifungals againstScedosporiumandPseudallescheriaisolates

摘要: In the present study, in vitro antifungal activities of five antipsychotic drugs (i.e., chlorpromazine hydrochloride, CPZ; trifluoperazine TPZ; amantadine hydrochloride; R-(-)-deprenyl and valproic acid sodium salt) conventional amphotericin B, AMB; caspofungin, CSP; itraconazole; terbinafine, TRB voriconazole, VRC) were investigated broth microdilution tests against four clinical environmental Scedosporium Pseudallescheria isolates. When used alone, phenothiazines CPZ TPZ exerted remarkable effects. Thus, their combinations with AMB, CSP, VRC, also examined combination agents, was able to act synergistically AMB cases one two isolates, respectively. all other cases, indifferent interactions revealed. Antagonism not observed between tested agents. These may establish a more effective less toxic therapy after further vivo studies for infections.