Qualitative and quantitative determination of YiXinShu Tablet using ultra high performance liquid chromatography with Q Exactive hybrid quadrupole orbitrap high-resolution accurate mass spectrometry.
作者： Zhi Sun , Zhuolun Li , Lihua Zuo , Zhenhui Wang , Lin Zhou
关键词:
摘要: To clarify and quantify the chemical profile of YiXinShu Tablet rapidly, a feasible accurate strategy was developed by applying ultra high performance liquid chromatography with Q Exactive hybrid quadrupole orbitrap high-resolution mass spectrometry. A total 105 components were identified, including 25 phenanthraquinones, 11 lactones, 19 lignans, 24 acids, 26 other compounds. Among them, major compounds unambiguously detected comparing reference standards. And these in three batches selected for quantitative determination. (Z)-Ligustilide, salvianic acid A, salvianolic B, rosmarinic abundant contents over 1 mg/g. The established analysis methods examined to be feasible. results show that spectrometry method has powerful qualitative ability promising application.
sci-hub.se 参考文章(17)
Daxin Chen, Shan Lin, Wen Xu, Mingqing Huang, Jianfeng Chu, Fei Xiao, Jiumao Lin, Jun Peng, Qualitative and Quantitative Analysis of the Major Constituents in Shexiang Tongxin Dropping Pill by HPLC-Q-TOF-MS/MS and UPLC-QqQ-MS/MS. Molecules. ,vol. 20, pp. 18597- 18619 ,(2015) , 10.3390/MOLECULES201018597
Lee-Hsin Shaw, Wei-Ming Chen, Tung-Hu Tsai, Identification of multiple ingredients for a Traditional Chinese Medicine preparation (bu-yang-huan-wu-tang) by liquid chromatography coupled with tandem mass spectrometry. Molecules. ,vol. 18, pp. 11281- 11298 ,(2013) , 10.3390/MOLECULES180911281
Wang Songsong, Xu Haiyu, Ma Yan, Wang Xuguang, Shi Yang, Huang Bin, Tang Shihuan, Zhang Yi, Li Defeng, Liang Rixin, Yang Hongjun, Characterization and rapid identification of chemical constituents of NaoXinTong capsules by UHPLC-linear ion trap/Orbitrap mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 111, pp. 104- 118 ,(2015) , 10.1016/J.JPBA.2015.01.020
Ming Ruan, Yi Li, Xin Li, Jianguang Luo, Lingyi Kong, Qualitative and quantitative analysis of the major constituents in Chinese medicinal preparation Guan-Xin-Ning injection by HPLC-DAD-ESI-MS(n). Journal of Pharmaceutical and Biomedical Analysis. ,vol. 59, pp. 184- 189 ,(2012) , 10.1016/J.JPBA.2011.10.007
Kevin P. Bateman, Markus Kellmann, Helmut Muenster, Robert Papp, Lester Taylor, Quantitative-Qualitative Data Acquisition Using a Benchtop Orbitrap Mass Spectrometer Journal of the American Society for Mass Spectrometry. ,vol. 20, pp. 1441- 1450 ,(2009) , 10.1016/J.JASMS.2009.03.002
A. Kaufmann, P. Butcher, K. Maden, S. Walker, M. Widmer, Comprehensive comparison of liquid chromatography selectivity as provided by two types of liquid chromatography detectors (high resolution mass spectrometry and tandem mass spectrometry): “Where is the crossover point?” Analytica Chimica Acta. ,vol. 673, pp. 60- 72 ,(2010) , 10.1016/J.ACA.2010.05.020
Feng Shi, Changchuan Guo, Liping Gong, Jun Li, Peng Dong, Jinling Zhang, Ping Cui, Shuyin Jiang, Yanxia Zhao, Su Zeng, Application of a high resolution benchtop quadrupole-Orbitrap mass spectrometry for the rapid screening, confirmation and quantification of illegal adulterated phosphodiesterase-5 inhibitors in herbal medicines and dietary supplements Journal of Chromatography A. ,vol. 1344, pp. 91- 98 ,(2014) , 10.1016/J.CHROMA.2013.12.030
Aifeng Liu, Guangbo Qu, Chaoli Zhang, Yan Gao, Jianbo Shi, Yuguo Du, Guibin Jiang, Identification of two novel brominated contaminants in water samples by ultra-high performance liquid chromatography-Orbitrap Fusion Tribrid mass spectrometer. Journal of Chromatography A. ,vol. 1377, pp. 92- 99 ,(2015) , 10.1016/J.CHROMA.2014.12.038
Xiao-Lin Zhang, Li-Fang Liu, Ling-Ying Zhu, Ying-Jia Bai, Qian Mao, Song-Lin Li, Shi-Lin Chen, Hong-Xi Xu, None, A high performance liquid chromatography fingerprinting and ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry chemical profiling approach to rapidly find characteristic chemical markers for quality evaluation of dispensing granules, a case study on Chuanxiong Rhizoma Journal of Pharmaceutical and Biomedical Analysis. ,vol. 88, pp. 391- 400 ,(2014) , 10.1016/J.JPBA.2013.09.023
Fengyun Wang, Qingqing Zhang, Zhiwei Lu, Qing Wang, Meiling Wang, Yuehong Liu, Shuang Fu, Xiaoyan Gao, Xudong Tang, Identification of chemical constituents in traditional Chinese medicine formula using HPLC coupled with linear ion trap-Orbitrap MS from high doses of medicinal materials to equivalent doses of formula: Study on Xiang-Sha-Liu-Jun-Zi-Jia-Jian granules Journal of Separation Science. ,vol. 39, pp. 1619- 1627 ,(2016) , 10.1002/JSSC.201501223