Striatal mechanisms in Parkinson's disease: new insights from computer modeling.

摘要: Abstract We review data and hypotheses concerning the functional anatomy of striatum role its corticostriatal nigrostriatal afferents in Parkinson's disease (PD). Starting from molecular mechanisms glutamatergic dopaminergic actions we have developed a compartmental model striatal principal neurons that displays significant degree biological realism. Simulations network projection under conditions likely to be found healthy subjects as well untreated therapeutic situations advanced PD provide clues dynamics neuronal interactions their possible effects on downstream motor structures generation positive negative symptoms. present tentative explanations symptoms rigidity akinesia leading predictions origin abnormal movements beneficial treatment. Although these attempts are not yet sufficient account for complexity clinical they can guide further empirical research foster fruitful between experimentalists, theoreticians, clinicians unraveling basal ganglia.