Effects of dexmedetomidine on regulating pulmonary inflammation in a rat model of ventilator-induced lung injury

摘要: Background We sought to elucidate the effects of dexmedetomidine, a selective 2-adrenergic receptor agonist, on regulation pulmonary inflammation in ventilator-induced lung injury (VILI) rat model. Methods A total 64 adult male Sprague-Dawley rats were assigned receive either standard ventilation (tidal volume 10 mL/kg; respiratory rate 50 breaths/minute), high-tidal (HV T : tidal 20 HV plus dexmedetomidine (0.5, 2.5 or 5.0 mg/kg per hour), hour) and yohimbine (the a2-adrenergic antagonist) ( n = 8 each group). The doses chosen correspond 1, 5 times clinical dose (0.5 hour). After maintaining for 4 hours, sacrificed inflammatory changes as well upregulation molecules evaluated. Results Histological arterial blood gas analyses confirmed that induced significant injury. also significantly increased concentrations chemokines (e.g. macrophage protein-2), cytokines tumor necrosis factor-a, interleukin [IL]-1b, IL-6), inducible nitric oxide synthase/nitric oxide, cyclooxygenase-2/prostaglandin E 2 . Dexmedetomidine at hour, but not 0.5 attenuated Moreover, these by yohimbine. Conclusion clinically relevant had no effect attenuating VILI. In contrast, approximately higher than These mediated, least part, receptor.