Metastasis of Head and Neck Squamous Cell Carcinoma

摘要: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide accounts for approximately 650,000 new diagnoses 350,000 deaths every year (Parkin, et al., 2005). In United States, HNSCC 5% of all cases diagnosed per year. Even with significant advances in operative skills such as reconstructive microvascular free tissue transfer, adjuvant therapies hyperfractioned radiotherapy concomitant chemoradiation, 5-year survival has not been markedly improved past three decades. The number annually amounts to over 42,000 individuals results more than 12,000 States. As known, a locoregional disease notoriously regional distant metastases, representing leading cause death patients. Although surgical resection isolated metastases beneficial some patients, overall efficacy surgery, chemotherapy or still limited. main reason poor may be that important prognostic factors these patients are only local control, but well.