Current advances in adenovirus nanocomplexes: more specificity and less immunogenicity.

摘要: An often overlooked issue in the field of adenovirus (Ad)-mediated cancer gene therapy is its limited capacity for effective systemic delivery. Although primary tumors can be treated effectively with intralesional injection conventional Ad vectors, metastasis difficult to cure. Systemic administration naked Ads leads acute accumulation particles liver, induction neutralizing antibody, short blood circulation half-life, non-specific biodistribution undesired organs, and low selective target disease site. Versatile strategies involving modification viral surfaces polymers nanomaterials have been designed purpose maximizing anti-tumor activity specificity by administration. Integration non-viral will substantially advance both fields, creating new concepts therapeutics. This review focuses on current advances development smart hybrid nanocomplexes based various design-based optimal