Signal transduction in human cutaneous melanoma and target drugs.

摘要: Malignant melanoma is an extremely aggressive and metastatic cancer, highly resistant to conventional treatment modalities. Understanding of fundamental mechanisms responsible for its genesis progression critical for development successful chemotherapeutic treatment. It becoming clear that results from complex changes in multiple signaling pathways control cell proliferation ability evade the death processes. Impairment or hyper-activation some components these may lead malignant transformation cancer development. In present review we consider current data on involvement such as cyclin/CDK, Ras/Raf/MEK/MAPK, JNK/c-Jun/AP-1, PI3K/Akt/PTEN/mTOR, IKK/I-κB/NF-κB, Wnt/β-catenin, Notch, Jak/STAT, MITF growth factors regulation cycle progression, apoptosis of human cutaneous melanoma. molecular aberrations underlie oncogenesis essential for improvement diagnosis, accurate prognosis assessment, rational design effective therapeutics. Inhibitors these pathways serve as promising tools anti-melanoma targeted therapy. Some novel target drugs are characterized.