Neuroprotective Mechanisms of 9-Hydroxy Epinootkatol Against Glutamate-Induced Neuronal Apoptosis in Primary Neuron Culture
作者： Hong Zhao , Zhi-Hong Ji , Chao Liu , Xin-Yu Yu
DOI: 10.1007/S12031-015-0511-Z
关键词:
摘要: Glutamate-induced neuronal apoptosis has been implicated in the pathogenesis of neurological disorders. 9-Hydroxy epinootkatol (9OHEN), a sesquiterpene compound with neuroprotective activity against glutamate-induced apoptosis, was isolated from Alpinia oxyphylla Miquel our previous study. In this study, we investigated mechanisms 9OHEN primary cultured neurons. The results study demonstrated that protected cortical neurons via inhibiting activation caspase-3, reactive oxygen species (ROS) production, nitric oxide (NO) and downregulating synthase (nNOS) expression. This suggest might have therapeutic potential treating glutamate-mediated diseases.
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sci-hub.se 参考文章(43)
Xinyu Yu, Lijia An, A serum- and antioxidant-free primary culture model of mouse cortical neurons for pharmacological screen and studies of neurotrophic and neuroprotective agents. Cellular and Molecular Neurobiology. ,vol. 22, pp. 197- 206 ,(2002) , 10.1023/A:1019870022977
YueMei Zhang, Bhagu R Bhavnani, Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens BMC Neuroscience. ,vol. 7, pp. 49- 49 ,(2006) , 10.1186/1471-2202-7-49
Angeles Almeida, Juan P. Bolaños, A transient inhibition of mitochondrial ATP synthesis by nitric oxide synthase activation triggered apoptosis in primary cortical neurons Journal of Neurochemistry. ,vol. 77, pp. 676- 690 ,(2001) , 10.1046/J.1471-4159.2001.00276.X
VL Dawson, VM Kizushi, PL Huang, SH Snyder, TM Dawson, Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice The Journal of Neuroscience. ,vol. 16, pp. 2479- 2487 ,(1996) , 10.1523/JNEUROSCI.16-08-02479.1996
David Schubert, Dana Piasecki, Oxidative glutamate toxicity can be a component of the excitotoxicity cascade The Journal of Neuroscience. ,vol. 21, pp. 7455- 7462 ,(2001) , 10.1523/JNEUROSCI.21-19-07455.2001
J OLNEY, Excitotoxicity, apoptosis and neuropsychiatric disorders. Current Opinion in Pharmacology. ,vol. 3, pp. 101- 109 ,(2003) , 10.1016/S1471-4892(02)00002-4
Chao Liu, Hong Zhao, Zhi-Hong Ji, Xin-Yu Yu, Neuroprotection of Atractylenolide III from Atractylodis macrocephalae Against Glutamate-Induced Neuronal Apoptosis Via Inhibiting Caspase Signaling Pathway Neurochemical Research. ,vol. 39, pp. 1753- 1758 ,(2014) , 10.1007/S11064-014-1370-7
Jing Xu, Yuanqiang Guo, Peng Zhao, Ping Guo, Yonggang Ma, Chunfeng Xie, Da-qing Jin, Liping Gui, Four new sesquiterpenes from Commiphora myrrha and their neuroprotective effects. Fitoterapia. ,vol. 83, pp. 801- 805 ,(2012) , 10.1016/J.FITOTE.2012.03.016
Ankita Mehta, Mayank Prabhakar, Puneet Kumar, Rahul Deshmukh, P.L. Sharma, Excitotoxicity: bridge to various triggers in neurodegenerative disorders. European Journal of Pharmacology. ,vol. 698, pp. 6- 18 ,(2013) , 10.1016/J.EJPHAR.2012.10.032
Xinyu Yu, Li Sun, Xueya Luo, Zhongqi Xu, Lijia An, Investigation of the neuronal death mode induced by glutamate treatment in serum-, antioxidant-free primary cultured cortical neurons Developmental Brain Research. ,vol. 145, pp. 263- 268 ,(2003) , 10.1016/J.DEVBRAINRES.2003.08.008