Composition for controlling chromogenesis including microrna

作者: Tae Ryong Lee , Bum Ho Bin , Hyun Jung Choi , Kyu Han Kim

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摘要: The present invention relates to a composition for whitening effect or the prevention of gray hair, which comprises antisense nucleic acid molecules sequence number 2, wherein has an miRNA 1 base complementary and can be hybridized miRNA. further method not only controlling chromogenesis in test materials but also screening expression control chromogenic genes, comprising steps of: transfecting, cell, 2; treating cell; confirming whether inhibit promote genes; color cell is changed. method, according invention, used hair.

参考文章(11)
Melissa G. Piper, Clay B. Marsh, Gregory A. Otterson, Serge P. Nana-Sinkham, Microrna expression profiling and targeting in peripheral blood in lung cancer ,(2008)
Z. Zhu, J. He, X. Jia, J. Jiang, R. Bai, X. Yu, L. Lv, R. Fan, X. He, J. Geng, R. You, Y. Dong, D. Qiao, K.-B. Lee, G.W. Smith, C. Dong, MicroRNA-25 functions in regulation of pigmentation by targeting the transcription factor MITF in Alpaca (Lama pacos) skin melanocytes. Domestic Animal Endocrinology. ,vol. 38, pp. 200- 209 ,(2010) , 10.1016/J.DOMANIEND.2009.10.004
Liang Zhang, Nicole Stokes, Lisa Polak, Elaine Fuchs, Specific MicroRNAs Are Preferentially Expressed by Skin Stem Cells To Balance Self-Renewal and Early Lineage Commitment Cell Stem Cell. ,vol. 8, pp. 294- 308 ,(2011) , 10.1016/J.STEM.2011.01.014
Shi-Lung Lin, Wu, Chen, Chang, Shi-Lung Lin, Mir-434-5p mediates skin whitening and lightening. Clinical, Cosmetic and Investigational Dermatology. ,vol. 1, pp. 19- 35 ,(2008) , 10.2147/CCID.S4181
Eric Miska, Ezequiel Alvarez-Saavedra, H. Horvitz, High throughput methods relating to microRNA expression analysis ,(2005)
Ke Zeng, Chunni Zhang, Chenyu Zhang, Yi Ba, Cheng Wang, Rui Liu, Pancreatic cancer marker, and detection method, kit and biochip thereof ,(2011)