Conjugated linoleic acid inhibits glucose metabolism, leptin and adiponectin secretion in primary cultured rat adipocytes
作者： P. Pérez-Matute , A. Marti , J.A. Martínez , M.P. Fernández-Otero , K.L. Stanhope
DOI: 10.1016/J.MCE.2007.01.013
关键词:
摘要: Conjugated linoleic acid (CLA) supplementation has been reported to induce insulin resistance in animals and humans, however, the underlying mechanisms remain unclear. The aim of this study was examine direct effects CLA on leptin adiponectin secretion, two hormones with actions known influence sensitivity. Isolated rat adipocytes were incubated (1-200microM) absence presence (1.6nM). inhibited both basal insulin-stimulated gene expression secretion (-30 -40%, P<0.05-0.01). also production (-20 P<0.05-0.01), but not insulin. (50-200muM) decreased glucose uptake (P<0.05-0.01) significantly increased proportion metabolized lactate (P<0.01). Insulin treatment partially prevented inhibitory induced a significant increase percentage lactate. A strong inverse relationship observed between anaerobic utilization decreases secretion. In addition, lipolysis adipogenic transcription factor PPARgamma by CLA. These results indicate that inhibits suggest metabolism may be involved these effects. inhibition could mediate Furthermore, contribute CLA-treated humans.
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sci-hub.se 参考文章(54)
Sebastiano Banni, Conjugated linoleic acid metabolism. Current Opinion in Lipidology. ,vol. 13, pp. 261- 266 ,(2002) , 10.1097/00041433-200206000-00005
E Simon, MT Macarulla, A Fernandez-Quintela, VM Rodriguez, MP Portillo, Body fat-lowering effect of conjugated linoleic acid is not due to increased lipolysis. Journal of Physiology and Biochemistry. ,vol. 61, pp. 363- 369 ,(2005) , 10.1007/BF03167053
MJ Moreno-Aliaga, JA Martínez, KL Stanhope, MP Fernández-Otero, PJ Havel, Effects of Trecadrine, a beta3-adrenergic agonist, on leptin secretion, glucose and lipid metabolism in isolated rat adipocytes. International Journal of Obesity. ,vol. 26, pp. 912- 919 ,(2002) , 10.1038/SJ.IJO.0802003
Carol R. Kepler, Kathleen P. Hirons, J.J. McNeill, S.B. Tove, Intermediates and Products of the Biohydrogenation of Linoleic Acid by Butyrivibrio fibrisolvens Journal of Biological Chemistry. ,vol. 241, pp. 1350- 1354 ,(1966) , 10.1016/S0021-9258(18)96781-5
M. Cnop, P. J. Havel, K. M. Utzschneider, D. B. Carr, M. K. Sinha, E. J. Boyko, B. M. Retzlaff, R. H. Knopp, J. D. Brunzell, S. E. Kahn, Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia. ,vol. 46, pp. 459- 469 ,(2003) , 10.1007/S00125-003-1074-Z
Roger S McLeod, Andrea M LeBlanc, Morgan A Langille, Patricia L Mitchell, Deborah L Currie, Conjugated linoleic acids, atherosclerosis, and hepatic very-low-density lipoprotein metabolism The American Journal of Clinical Nutrition. ,vol. 79, ,(2004) , 10.1093/AJCN/79.6.1169S
J. M. Griinari, B. A. Corl, S. H. Lacy, P. Y. Chouinard, K. V. V. Nurmela, D. E. Bauman, Conjugated Linoleic Acid Is Synthesized Endogenously in Lactating Dairy Cows by Δ9-Desaturase Journal of Nutrition. ,vol. 130, pp. 2285- 2291 ,(2000) , 10.1093/JN/130.9.2285
S.F. Chin, W. Liu, J.M. Storkson, Y.L. Ha, M.W. Pariza, Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens Journal of Food Composition and Analysis. ,vol. 5, pp. 185- 197 ,(1992) , 10.1016/0889-1575(92)90037-K
Y W Wang, P J H Jones, Conjugated linoleic acid and obesity control: efficacy and mechanisms International Journal of Obesity. ,vol. 28, pp. 941- 955 ,(2004) , 10.1038/SJ.IJO.0802641
Mathias Fasshauer, Johannes Klein, Susanne Neumann, Markus Eszlinger, Ralf Paschke, Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes. Biochemical and Biophysical Research Communications. ,vol. 290, pp. 1084- 1089 ,(2002) , 10.1006/BBRC.2001.6307