Candidate gene-environment interactions in breast cancer.
作者： Olivia Fletcher , Frank Dudbridge
DOI: 10.1186/S12916-014-0195-1
关键词:
摘要: Gene-environment interactions have the potential to shed light on biological processes leading disease, identify individuals for whom risk factors are most relevant, and improve accuracy of epidemiological models. We review progress that has been made in investigating gene-environment field breast cancer. Although several large-scale analyses carried out, only a few significant reported. One these, an interaction between CASP8-rs1045485 alcohol consumption replicated, but others not, including LSP1- rs3817198 parity, 1p11.2-rs11249433 ever being parous. False positive may arise if gene environment correlated causal variant is less frequent than tag SNP. conclude while much this area it still too soon tell whether will fulfil their promise. Before we can make assessment need replicate (or refute) reported interactions, variants underlie tag-SNP associations validate next generation
biomedcentral.com
springer.com
core.ac.uk
lshtm.ac.uk
paperity.org参考文章(20)
W. James Gauderman, Pingye Zhang, John L. Morrison, Juan Pablo Lewinger, Finding novel genes by testing G × E interactions in a genome-wide association study. Genetic Epidemiology. ,vol. 37, pp. 603- 613 ,(2013) , 10.1002/GEPI.21748
J. Y. Dai, C. Kooperberg, M. Leblanc, R. L. Prentice, Two-stage testing procedures with independent filtering for genome-wide gene-environment interaction. Biometrika. ,vol. 99, pp. 929- 944 ,(2012) , 10.1093/BIOMET/ASS044
A J Swerdlow, M E Jones, M J Schoemaker, J Hemming, D Thomas, J Williamson, A Ashworth, The Breakthrough Generations Study: design of a long-term UK cohort study to investigate breast cancer aetiology. British Journal of Cancer. ,vol. 105, pp. 911- 917 ,(2011) , 10.1038/BJC.2011.337
Douglas F Easton, Karen A Pooley, Alison M Dunning, Paul DP Pharoah, Deborah Thompson, Dennis G Ballinger, Jeffery P Struewing, Jonathan Morrison, Helen Field, Robert Luben, Nicholas Wareham, Shahana Ahmed, Catherine S Healey, Richard Bowman, SEARCH collaborators Luccarini Craig 61 Conroy Don 61 Shah Mitul 61 Munday Hannah 61 Jordan Clare 61 Perkins Barbara 61 West Judy 61 Redman Karen 61 Driver Kristy 61, Kerstin B Meyer, Christopher A Haiman, Laurence K Kolonel, Brian E Henderson, Loic Le Marchand, Paul Brennan, Suleeporn Sangrajrang, Valerie Gaborieau, Fabrice Odefrey, Chen-Yang Shen, Pei-Ei Wu, Hui-Chun Wang, Diana Eccles, D Gareth Evans, Julian Peto, Olivia Fletcher, Nichola Johnson, Sheila Seal, Michael R Stratton, Nazneen Rahman, Georgia Chenevix-Trench, Stig E Bojesen, Børge G Nordestgaard, Christen K Axelsson, Montserrat Garcia-Closas, Louise Brinton, Stephen Chanock, Jolanta Lissowska, Beata Peplonska, Heli Nevanlinna, Rainer Fagerholm, Hannaleena Eerola, Daehee Kang, Keun-Young Yoo, Dong-Young Noh, Sei-Hyun Ahn, David J Hunter, Susan E Hankinson, David G Cox, Per Hall, Sara Wedren, Jianjun Liu, Yen-Ling Low, Natalia Bogdanova, Peter Schürmann, Thilo Dörk, Rob AEM Tollenaar, Catharina E Jacobi, Peter Devilee, Jan GM Klijn, Alice J Sigurdson, Michele M Doody, Bruce H Alexander, Jinghui Zhang, Angela Cox, Ian W Brock, Gordon MacPherson, Malcolm WR Reed, Fergus J Couch, Ellen L Goode, Janet E Olson, Hanne Meijers-Heijboer, Ans van den Ouweland, André Uitterlinden, Fernando Rivadeneira, Roger L Milne, Gloria Ribas, Anna Gonzalez-Neira, Javier Benitez, John L Hopper, Margaret McCredie, Melissa Southey, Graham G Giles, Chris Schroen, Christina Justenhoven, Hiltrud Brauch, Ute Hamann, Yon-Dschun Ko, Amanda B Spurdle, Jonathan Beesley, Xiaoqing Chen, AOCS Management Group Bowtell David 146 Green Adele 82 deFazio Anna 147 Chenevix-Trench Georgia 82 Gertig Dorota 111 Webb Penny 82, Arto Mannermaa, Veli-Matti Kosma, Vesa Kataja, Jaana Hartikainen, Nicholas E Day, David R Cox, Bruce AJ Ponder, None, Genome-wide association study identifies novel breast cancer susceptibility loci Nature. ,vol. 447, pp. 1087- 1093 ,(2007) , 10.1038/NATURE05887
David J. Hunter, Gene–environment interactions in human diseases Nature Reviews Genetics. ,vol. 6, pp. 287- 298 ,(2005) , 10.1038/NRG1578
Robert Welch, Amy Hutchinson, Junwen Wang, Kai Yu, Nilanjan Chatterjee, Nick Orr, Walter C Willett, Graham A Colditz, Regina G Ziegler, Christine D Berg, Saundra S Buys, Catherine A McCarty, Heather Spencer Feigelson, Eugenia E Calle, Michael J Thun, Richard B Hayes, Margaret Tucker, Daniela S Gerhard, Joseph F Fraumeni, Robert N Hoover, Gilles Thomas, Stephen J Chanock, David J Hunter, Peter Kraft, Kevin B Jacobs, David G Cox, Meredith Yeager, Susan E Hankinson, Sholom Wacholder, Zhaoming Wang, A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer Nature Genetics. ,vol. 39, pp. 870- 874 ,(2007) , 10.1038/NG2075
Rebecca Hein, Lars Beckmann, Jenny Chang-Claude, Sample size requirements for indirect association studies of gene–environment interactions (G × E) Genetic Epidemiology. ,vol. 32, pp. 235- 245 ,(2008) , 10.1002/GEPI.20298
Roger L Milne, Mia M Gaudet, Amanda B Spurdle, Peter A Fasching, Fergus J Couch, Javier Benítez, Jose Ignacio Arias Perez, M Pilar Zamora, Núria Malats, Isabel dos Santos Silva, Lorna J Gibson, Olivia Fletcher, Nichola Johnson, Hoda Anton-Culver, Argyrios Ziogas, Jonine Figueroa, Louise Brinton, Mark E Sherman, Jolanta Lissowska, John L Hopper, Gillian S Dite, Carmel Apicella, Melissa C Southey, Alice J Sigurdson, Martha S Linet, Sara J Schonfeld, D Michal Freedman, Arto Mannermaa, Veli-Matti Kosma, Vesa Kataja, Paeivi Auvinen, Irene L Andrulis, Gord Glendon, Julia A Knight, Nayana Weerasooriya, Angela Cox, Malcolm WR Reed, Simon S Cross, Alison M Dunning, Shahana Ahmed, Mitul Shah, Hiltrud Brauch, Yon-Dschun Ko, Thomas Bruening, GENICA Network hiltrud. brauch@ ikp-stuttgart. de, Diether Lambrechts, Joke Reumers, Ann Smeets, Shan Wang-Gohrke, Per Hall, Kamila Czene, Jianjun Liu, Astrid K Irwanto, Georgia Chenevix-Trench, Helene Holland, kConFab Georgia. Trench@ qimr. edu. au, AOCS Georgia. Trench@ qimr. edu. au, Graham G Giles, Laura Baglietto, Gianluca Severi, Stig E Bojensen, Børge G Nordestgaard, Henrik Flyger, Esther M John, Dee W West, Alice S Whittemore, Celine Vachon, Janet E Olson, Zachary Fredericksen, Matthew Kosel, Rebecca Hein, Alina Vrieling, Dieter Flesch-Janys, Judith Heinz, Matthias W Beckmann, Katharina Heusinger, Arif B Ekici, Lothar Haeberle, Manjeet K Humphreys, Jonathan Morrison, Doug F Easton, Paul D Pharoah, Montserrat García-Closas, Ellen L Goode, Jenny Chang-Claude, None, Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study. Breast Cancer Research. ,vol. 12, pp. 1- 11 ,(2010) , 10.1186/BCR2797
Simon N Stacey, Andrei Manolescu, Patrick Sulem, Thorunn Rafnar, Julius Gudmundsson, Sigurjon A Gudjonsson, Gisli Masson, Margret Jakobsdottir, Steinunn Thorlacius, Agnar Helgason, Katja K Aben, Luc J Strobbe, Marjo T Albers-Akkers, Dorine W Swinkels, Brian E Henderson, Laurence N Kolonel, Loic Le Marchand, Esther Millastre, Raquel Andres, Javier Godino, Maria Dolores Garcia-Prats, Eduardo Polo, Alejandro Tres, Magali Mouy, Jona Saemundsdottir, Valgerdur M Backman, Larus Gudmundsson, Kristleifur Kristjansson, Jon T Bergthorsson, Jelena Kostic, Michael L Frigge, Frank Geller, Daniel Gudbjartsson, Helgi Sigurdsson, Thora Jonsdottir, Jon Hrafnkelsson, Jakob Johannsson, Thorarinn Sveinsson, Gardar Myrdal, Hlynur Niels Grimsson, Thorvaldur Jonsson, Susanna von Holst, Barbro Werelius, Sara Margolin, Annika Lindblom, Jose I Mayordomo, Christopher A Haiman, Lambertus A Kiemeney, Oskar Th Johannsson, Jeffrey R Gulcher, Unnur Thorsteinsdottir, Augustine Kong, Kari Stefansson, None, Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. Nature Genetics. ,vol. 39, pp. 865- 869 ,(2007) , 10.1038/NG2064
Frank Dudbridge, Olivia Fletcher, Gene-environment dependence creates spurious gene-environment interaction. American Journal of Human Genetics. ,vol. 95, pp. 301- 307 ,(2014) , 10.1016/J.AJHG.2014.07.014