Association analyses of genetic variants in long non-coding RNA MALAT1 with breast cancer susceptibility and mRNA expression of MALAT1 in Chinese Han population.
作者： Rui Peng , Chenglin Luo , Qiaoyun Guo , Jingjing Cao , Qian Yang
DOI: 10.1016/J.GENE.2017.11.013
关键词:
摘要: The long non-coding RNA (lncRNA) Metastasis-associated lung adenocarcinoma transcript 1(MALAT1) has been implicated in breast cancer (BC). Polymorphisms MALAT1 may play a vital role the progress of by its regulation function. However, potential genetic variants affecting development BC is rarely explored. In our current molecular epidemiology study, all three tagging SNPs (rs3200401, rs619586 and rs7927113) lncRNA were selected for genotyping 487BCE patients 489 cancer-free controls Chinese Han population, futher experiment quantitative real-time (qRT) PCR was conducted to examine relative expression MALAT1. results showed that individuals with genotype AG decreased risk codominant model (OR: 0.684, 95%CI: 0.478-0.979), dominant mode 0.675, 0.479-0.951) over-dominant 0.692, 0484-0.989). Also, qRT-PCR revealed (0.827±0.490), GG (0.511±0.149) AG+GG genotypes (0.743±0.447) significantly lower than AA (1.511±0.737). addition, females CT rs3200401 had 0.75, 0.559-1.007) 0.741, 0.552-0.993). summary, implied associated susceptibility BC, meaningful alteration might affect corresponding mRNA
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