SNP rs2071095 in LincRNA H19 is associated with breast cancer risk.

摘要: An increasing number of long intergenic non-coding RNAs (lincRNAs) appear to play critical roles in cancer development and progression. To assess the association between SNPs that reside regions lincRNAs breast risk, we performed a large case-control study China. We carried out two-stage including 2881 cases 3220 controls. In stage I, genotyped 17 independent (r2 < 0.5) located 6 tumor-related by using TaqMan platform. II, potentially associated with risk were replicated an population. Quantitative real-time PCR was used measure H19 levels tissues from 228 patients different genotypes. identified 2 significantly I (P < 0.05), but not II. combined data found that, compared rs2071095 CC genotype, AA CA + AA genotypes decreased (adjusted OR 0.83, 95% CI 0.69–0.99; adjusted 0.88, 0.80–0.98, respectively). Stratified analyses showed estrogen receptor (ER)-positive (P = 0.002), ER-negative ones (P = 0.332). Expression genotype lower than those genotype. may contribute susceptibility Chinese women via affecting expression. The mechanisms underlying remain be investigated.