The space of ultrametric phylogenetic trees.

作者: Alex Gavryushkin , Alexei J. Drummond

DOI: 10.1016/J.JTBI.2016.05.001

关键词:

摘要: The reliability of a phylogenetic inference method from genomic sequence data is ensured by its statistical consistency. Bayesian methods produce sample trees the posterior distribution given data. Hence question consistency such equivalent to summary sample. More generally, tree space used analyse In this paper, we consider two standard parameterisations time-trees in evolutionary models: inter-coalescent interval lengths and absolute times divergence events. For each these introduce natural metric on ultrametric trees. We compare introduced spaces with existing models formulate several formal requirements that must possess order be satisfactory for analysis, justify them. show only few known constructions satisfy requirements. However, our results suggest basic are not enough distinguish between choice requires additional properties considered. Particularly, minimising square distance might different parameterisations. This suggests further fundamental insight needed into problem methods.

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