Sex and age dependencies of cerebral blood volume changes during cognitive activation: a multichannel near-infrared spectroscopy study

作者: Masaki Kameyama , Masato Fukuda , Toru Uehara , Masahiko Mikuni

DOI: 10.1016/J.NEUROIMAGE.2004.03.050

关键词:

摘要: In this study, we measured the change in cerebral hemoglobin concentrations during a cognitive task using multichannel near-infrared spectroscopy (NIRS), and investigated relationship between regional blood volume sex, age, performance. Thirty-nine healthy volunteers (24 males 15 females; mean 33.0 years) participated after giving their informed consent performed word fluency task. The relative oxy-hemoglobin concentration ([oxy-Hb]) was frontal temporal probes with two sets of 24-channel NIRS machines. effects performance on [oxy-Hb] changes were analyzed analysis covariance: as independent variables, dependent years education covariates. increase significant many channels for that is most prominent effect, few age: increases larger than females, young middle-aged. not performance, but subjects low tended to be those high results demonstrated could detect activation tasks clarify sex- age-dependent differences such activation. Sex- activation, present should considered when interpreting volume, flow, glucose metabolism data.

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