A possible molecular mechanism for the inhibition of cysteine proteases by salicylaldehyde N-acylhydrazones and related compounds
作者： D.R Ifa , C.R Rodrigues , R.B de Alencastro , C.A.M Fraga , E.J Barreiro
DOI: 10.1016/S0166-1280(99)00307-3
关键词:
摘要: Abstract Salicylaldehyde N-acylhydrazones are inhibitors of some cysteine proteases as in the case Plasmodium falciparum trophozoite protease (TCP), or Trypanosoma cruzi cruzipain. Based on an AM1 theoretical study title compounds, we propose a new mechanism to explain greater activity possessing o-hydroxyarylaldehyde hydrazone framework. This involves intramolecular proton transfer resulting transient quinonemethyde-like tautomeric form with electrophilic center, which can act Michael acceptor attack active center enzyme.
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