作者: Junichi Mitsuyama , Kazuya Hayashi , Tetsumi Yamakawa , Hiroyo Kawafuchi , Tokunori Kito
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摘要: Novel quinolonecarboxylic acid derivatives represented by general formula (1) which have potent antibacterial effects on gram-positive bacteria, in particular, Propionibacterium acnes, wherein R1 represents hydrogen or a carboxyl-protective group; R2 optionally substituted cycloalkyl; R3 hydrogen, halogeno, alkyl, alkoxy alkylthio, protected hydroxy amino, nitro; R4 alkyl alkoxy; Z alkenyl, cycloalkyl, alkoxy, amino pyridin-4-yl pyridin-3-yl having one more substituents selected from among and amino.