Relationships between emphysema and airways metrics at High-Resolution Computed Tomography (HRCT) and ventilatory response to exercise in mild to moderate COPD patients.

摘要: Abstract Background and purpose In Chronic Obstructive Pulmonary Disease (COPD) patients, the opportunity to carry out a thoracic high-resolution CT (HRCT) scan perform an incremental cardiopulmonary exercise test (CPET) increases possibility identify different clinical features of disease. The aim our study was evaluate relationships between HRCT metrics (on emphysema by low attenuation areas-LAA% airways wall area-WA%) CPET variables related dynamic response in terms elastic balance (Δ rest-to-peak IC/TLC) ventilation capacity for carbon dioxide output (V E /V CO2 slope V intercept ). Methods We prospectively enrolled COPD outpatients from University Hospital Parma. Data on anthropometrics characteristics, lung function, (LAA% WA%) IC/TLC, ) were recorded. Results Fifty-one mild moderate patients (66% males; median age 70 y; mean FEV 1 56% pred.) study. LAA% demonstrated significant correlation with Δ IC/TLC (r = 0.405, p = 0.005 r = 0.453, p = 0.001, respectively), while WA% (r = −0.333, p = 0.020). multivariate regression models, after adjustment oxygen uptake (peak O2 physical workload), LAA only independent predictor (β 0.774, SE 0.334, p = 0.025) 0.155, 0.053, β 0.305, 0.123, p = 0.018, respectively). instead predicted −0.097, 0.042, p = 0.027). Conclusion (LAA) (WA) have close characteristics ventilatory exercise. particular, we able show that is exercise-induced .