Pulmonary fibrosis associated with tracheobronchial aspiration. A study of the frequency of hiatal hernia and gastroesophageal reflux in interstitial pulmonary fibrosis of obscure etiology.

摘要: Tracheobronchial aspiration of gastric secretions has been suggested in published reports as a possible cause for idiopathic pulmonary fibrosis. Forty-eight 131 patients with roentgenographic evidence fibrosis had no established etiologic diagnosis after individualized evaluations. They were prospectively studied by upper gastrointestinal series to determine the incidence gastroesophageal reflux. The both hiatal hernia and reflux statistically higher study group than 270 age-matched controls who usual indications; (2) subgroup 15 serologic which immune-mediated diseases; (3) 23 etiology. could be further characterized clinical presentations, low maximum-mid-expiratory flow rates, lung biopsies compatible interstitial These observations other cited are supportive concept that repeated, small tracheobronchial aspirations acid over long period time may