Combination of sotalol with the class I B substances mexiletine or tocainide in complex ventricular extrasystole

摘要: In 34 patients with ventricular tachyarrhythmias the effect of antiarrhythmic therapy sotalol (160-320 mg p.o.) in combination type-I-B-agent mexiletine (600-800 or tocainide (800-1200 was studied by Holter monitoring. all 2.2 +/- 1.1 drugs trials had failed, including amiodarone 8 and beta blocking substances 15 patients. The reduced ectopic beats 79% complex arrhythmias (pairs salvoes) 85%. A significant reduction (greater than 80%) reached 74% patients, pairs salvoes 90%) 79%. There no difference efficacy between sotalol/mexiletine sotalol/tocainide. Intervals resting ECG laboratory values did not change significantly. 5 sotalol/tocainide 1 patient sotalol/mexiletine, side effects were observed which necessitated discontinuation treatment. results show that sotalol, tocainide, has a potent otherwise drug-refractory arrhythmias.