Osteoblastic insufficiency is responsible for maintenance of osteopenia after loss of ovarian function in experimental beagle dogs

摘要: Bone loss developing after cessation of ovarian function in humans represents a major health problem. To establish the value ovariohysterectomy female beagle dogs as model for bone and to study static dynamic parameters associated with negative balance occurring function, we performed iliac crest biopsies before 4 months eight five sham-operated controls. Cessation was documented by an increase serum levels LH weeks ovariohysterectomy. There no change calcium, phosphorus, creatinine during study. Cancellous mass trabecular mean wall thickness decreased significantly (P < 0.01). In addition, number osteoblasts increased formation rate per osteoblast, that is, activity bone-forming cells, Parameters resorption were not signif...