Cocaine Self-Administration and Abstinence Modulate NMDA Receptor Subunits and Active Zone Proteins in the Rat Nucleus Accumbens.

摘要: Cocaine-induced plasticity in the glutamatergic transmission and its N-methyl-d-aspartate (NMDA) receptors are critically involved development of substance use disorder. The presynaptic active zone proteins control structural synaptic plasticity; however, we still far from understanding molecular determinants important for cocaine seeking behavior. aim this study was to investigate effect self-administration different conditions forced abstinence on composition NMDA receptor subunits levels proteins, i.e., Ras-related protein 3A (Rab3A), Rab3 interacting molecules 1 (RIM1) mammalian uncoordinated 13 (Munc13) rat nucleus accumbens. We found an up-regulation accumbal GluN1 GluN2A following that paralleled by increase Munc13 RIM1 levels. At same time, also demonstrated abolished changes (except higher after with extinction training), while concentration shown rats housed enriched environment. In conclusion, is associated specific subunit related new targets controlling neurotransmitter release. Moreover, observed training environment protein, respectively, may represent a potential regulatory step cocaine-seeking