The Role of the DNA Damage Checkpoint Pathway in Intraductal Papillary Mucinous Neoplasms of the Pancreas

摘要: Purpose: Intraductal papillary mucinous neoplasms (IPMN) are known to show a transition from adenoma carcinoma accompanied by several molecular abnormalities. ATM-Chk2-p53 DNA damage checkpoint activation, which is involved in prevention of the progression tumors, was analyzed evaluate role IPMNs. Experimental Design: One hundred and twenty-eight IPMNs were classified into four groups (intraductal adenoma, borderline IPMN, noninvasive intraductal carcinoma, invasive carcinoma) stained immunohistochemically using antibody for Thr 68 -phosphorylated Chk2. Expression ATM, Chk2, p21 WAF1 accumulation p53 also analyzed. Results: Chk2 phosphorylation shown all adenomas showed significant decreasing trend with atypia ( P exhibited tendency Conclusion: Our findings indicate that activation occurs early stage prevents their progression. It suggested disturbance pathway due inactivation or mutation contributes carcinogenesis