Fibroblast growth factor receptor 3 (FGFR3) aberrations in muscle-invasive urothelial carcinoma.
作者： Young Saing Kim , Kyung Kim , Ghee-Young Kwon , Su Jin Lee , Se Hoon Park
DOI: 10.1186/S12894-018-0380-1
关键词:
摘要: Recent studies suggest that FGFR3 is a potential therapeutic target in urothelial carcinoma (UC). The purpose of this study was to evaluate the rates and types aberrations patients with muscle-invasive UC who received radical resection. We analyzed surgical tumor samples from 74 had cystectomy (n = 40) or ureteronephrectomy (n = 34). Ion AmpliSeq Cancer Hotspot Panel v2 nCounter Copy Number Variation Assay were used detect aberrations. Fifty-four (73%) high-grade tumors, 62% lymph node involvement. Sixteen (22%) harbored alterations, most common which mutations (n = 13): Y373C (n = 3), N532D R248C (n = 2), S249C (n = 1), G370C S657S A797P 746_747insG (n = 1). Three additional FGFR3-TACC3 rearrangement. frequency higher bladder (25%) than renal pelvis ureter (18%) but difference not statistically significant (P = 0.444). Genes co-aberrant included APC (88%), PDGFRA (81%), RET (69%), TP53 (69%). report Korean UC. Patients fusion may constitute candidates for novel FGFR-targeted therapy perioperative setting.
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