Hyaluronan in Acute Lung Injury

摘要: Hyaluronan in HMW forms serves as an organizer of the extracellular matrix lung, but LMW act signaling molecules that are involved production inflammatory cytokines. hyaluronan is produced either by breakdown or de novo synthesis HAS3. regulates cytokine through binding to cell surface receptors, CD44, RHAMM and TLRs. We have shown VILI, a form ALI, upregulation HAS3 plays important role chemokines neutrophil infiltration found VILI. hyaluronan-induced IL-8 lung cells dependent on NF-κB JNK/AP-1 activation. Our clinical studies patients at risk ALI with ALI/ARDS suggest may play pathogenesis offer targets for new treatment modalities.