Accumulation of hyaluronan (hyaluronic acid) in the lung in adult respiratory distress syndrome.

摘要: The concentrations of hyaluronan (HA) were measured in bronchoalveolar lavage (BAL) fluid and serum from 12 patients with adult respiratory distress syndrome (ARDS). median BAL HA concentration was 353 micrograms/L, about six times higher than that seen control (p less 0.001). value 619 which a 30-fold increase compared the Another connective tissue component, type III procollagen peptide, not recovered significant amounts during ARDS, but it appeared bloodstream increased Obtained recovery ARDS cannot be explained by an enhanced passive leakage because alveolar-capillary permeability, rather could reflect mobilization lung interstitial hydrostatic mechanisms. Alternatively, appearance alveolar space might synthesis HA. An production can possibly mediated, directly or indirectly, activated complement components, since relationship between plasma C3a des Arg (r = 0.61; p 0.05). observed accumulation small airways may expected to immobilize water thereby contribute edema. inverse correlation 0.71; 0.01) pulmonary oxygenation index (PaO2/inspired oxygen fraction) supports such hypothesis.